Board-certified plastic surgeon · Ashley Howarth, MD, FACS

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Pigment Control Crème

Price range: $53.00 through $105.00

2.7 fl oz / 80 mL · 1 fl oz / 30 mL

A physician-dispensed pigment treatment (Rx only). Hydroquinone 4% produces a gradual, reversible lightening of hyperpigmentation such as chloasma, melasma, freckles and age spots, and glycolic acid in the base helps promote a more even tone. Applied as a thin layer to affected areas twice daily under physician direction.

When to use

When to useMorningEvening

Routine step

Treat / pigment

Best for

Mature or sun-damaged, Rx only

This brand ships only through licensed practices. Request it here and our team confirms availability and pricing, usually the same day.

Why Dr. Howarth recommends it
A physician-dispensed formula, provided under Dr. Howarth’s direction as the pigment step in ZO programs for melasma and stubborn sun damage. It is the same 4% hydroquinone crème that anchors ZO’s Pigment Control Program, so a regimen continues at home without changing products.
  • Gradual bleaching of hyperpigmentation such as melasma and freckles
  • Helps promote a more even skin tone
  • Reversible depigmentation under physician direction

Apply 2 pumps (about 1 g) as a thin layer to affected areas twice a day, or as directed by your physician, and always use sunscreen. Reassess with your provider at 8–12 weeks if there is no improvement; not for use under 12 or during pregnancy without medical advice; patch test on an unbroken area first and check within 24 hours; avoid the eyes and discontinue if irritation develops.

  • Hydroquinone 4% (active): produces reversible depigmentation by inhibiting melanin formation
  • Glycolic acid: alpha hydroxy acid that helps promote even tone; increases sun sensitivity
  • Vitamin C and E antioxidants: ascorbic acid, ascorbyl palmitate and tocopheryl acetate in the base
Active Ingredient: Hydroquinone 4%. Inactive Ingredients: Aqua/Water/Eau, Ascorbic Acid, Ascorbyl Palmitate, Beta-Glucan, Caprylyl Glycol, Cetyl Alcohol, Chlorphenesin, Dioscorea Villosa (Wild Yam) Root Extract, Disodium EDTA, Glycerin, Glycolic Acid, Phenoxyethanol, Quillaja Saponaria Bark Extract, Smilax Aristolochiifolia Root Extract, Sodium Hydroxide, Sodium Lauryl Sulfate, Sodium Metabisulfite, Sodium Sulfite, Stearyl Alcohol, Tocopheryl Acetate, Yucca Schidigera Root Extract.

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Pigment Control Crème

Price range: $53.00 through $105.00
2.7 fl oz / 80 mL · 1 fl oz / 30 mL