Board-certified plastic surgeon · Ashley Howarth, MD, FACS

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Pigment Control + Blending Crème

Price range: $53.00 through $105.00

2.7 fl oz / 80 mL · 1 fl oz / 30 mL

The blending step in ZO’s physician-dispensed pigment programs (Rx only). Hydroquinone 4%, which ZO calls the optimal concentration for melanin inhibition, produces gradual, reversible lightening of chloasma, melasma, freckles and age spots. An emollient base distinguishes it from Pigment Control Crème, and it is applied thinly to affected areas twice daily as your physician directs.

When to use

When to useMorningEvening

Routine step

Treat / pigment

Best for

Mature or sun-damaged, Rx only

This brand ships only through licensed practices. Request it here and our team confirms availability and pricing, usually the same day.

Why Dr. Howarth recommends it
A physician-dispensed formula, provided under Dr. Howarth’s direction alongside Pigment Control Crème as the second half of a ZO pigment program. The emollient base is the practical difference, and it is the formula ZO pairs with Pigment Control Crème in its program.
  • 4% hydroquinone, ZO’s optimal concentration for melanin inhibition
  • Gradual bleaching of melasma, freckles and age spots
  • Emollient base distinguishes it from Pigment Control Crème

Apply 2 pumps (about 1 g) as a thin application to affected areas twice a day, or as directed by your physician, and always use sunscreen; the product label says if it should be rubbed in. Reassess with your provider at 8–12 weeks if there is no improvement; not for use under 12 or during pregnancy without medical advice; patch test on an unbroken area first and check within 24 hours; avoid the eyes and discontinue if irritation develops.

  • Hydroquinone 4% (active): reversible depigmentation by inhibiting the oxidation of tyrosine
  • Glycolic acid: alpha hydroxy acid; increases sun sensitivity during use
  • Ethylhexyl palmitate and phenyl trimethicone: emollient base that sets the blending crème apart
Active Ingredient: Hydroquinone 4%. Inactive Ingredients: Ascorbic Acid, Ascorbyl Palmitate, Beta-Glucan, Caprylyl Glycol, Cetyl Alcohol, Chlorphenesin, Dioscorea Villosa (Wild Yam) Root Extract, Disodium EDTA, Ethylhexyl Palmitate, Glycerin, Glycolic Acid, Palmitic Acid, Phenoxyethanol, Phenyl Trimethicone, Quillaja Saponaria Bark Extract, Smilax Aristolochiifolia Root Extract, Sodium Hydroxide, Sodium Lauryl Sulfate, Sodium Metabisulfite, Sodium Sulfite, Stearyl Alcohol, Tocopheryl Acetate, Water, Yucca Schidigera Root Extract.

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Pigment Control + Blending Crème

Price range: $53.00 through $105.00
2.7 fl oz / 80 mL · 1 fl oz / 30 mL